The measuring principle

MedStorm’s Pain-Nociceptive Sensor detects skin conductance peaks, mirroring firing in the skin sympathetic nerves with acetylcholine acting on muscarinic receptors. The reaction time is 2 seconds.

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The skin sympathetic nerves are activated by emotional stimuli like pain, inducing emotional sweating palmar (inside of the hand) and plantar (under sole of the foot):

Electrode placement (palmar or plantar) to assess emotional sweating: